目的:评估机器人袖式肺叶切除术的安全性和有效性。方法:回顾性收集 2015 年 9 月 ~2020 年 10 月于浙江大学医学院附属第一医院接受机器人和胸腔镜袖式肺叶切除术的 22 例非小细胞肺癌患者的临床资料。根据手术方式将患者分为机器人组和胸腔镜组,其中机器人组 8 例(男 7 例,女 1 例),平均年龄(65.9±5.4)岁;胸腔镜组 14 例(男 14 例,女 0 例),平均年龄(63.5±9.5)岁。对两组患者进行基线特征比较,并评价两组患者围手术期资料。结果:对两组患者进行基线特征比较,发现组间年龄、性别、吸烟史等因素无统计学差异。与胸腔镜组相比,机器人组患者的淋巴清扫站数更多(P=0.025),但住院总费用更高(P<0.001)。结论:机器人袖式肺叶切除术具有不亚于胸腔镜手术的安全性,且能清扫更多淋巴结站数。
Objective: To investigate the safety and efficiency of robotic sleeve lobectomy. Methods: The clinical data of 22 patients with early-stage non-small cell lung cancer who underwent robotic or thoracoscopic sleeve lobectomy in the First Affiliated Hospital to Zhejiang University School of Medicine from September 2015 to October 2020 were retrospectively collected. Patients were divided into two groups according to different surgical approaches. 8 patients in the robotic group, including 7 males and 1 female, with an average age of (65.9±5.4) years old. 14 patients in the thoracoscopic group, including 14 males and 0 female, with an average age of (63.5±9.5) years old. The baseline characteristics of patients in the two groups were compared, and the perioperative outcomes of the two groups were evaluated. Results: Factors such as age, gender and smoking history were not statistically different between the two groups. Compared with the thoracoscopic group, the robotic group had more lymph stations dissected (P=0.025) and higher hospitalization cost (P<0.001). Conclusion: Robotic sleeve lobectomy has similar safety to thoracoscopic surgery, but robotic sleeve lobectomy can do better than thoracoscopic surgery in lymph node station dissection.
收稿日期:2021-03-12 录用日期:2021-08-24
Received Date: 2021-03-12 Accepted Date: 2021-08-24
基金项目:国家重点研发计划(2017YFC0113500);浙江省重大科技专项计划项目(2020C03058);浙江省肺部肿瘤诊治技术研究中心(JBZX-202007)
Foundation Item: National Key Research and Development Program of China(2017YFC0113500); Major Science and Technology Projects of Zhejiang Province(2020C03058); Lung Tumor Diagnosis and Treatment Technology Research Center of Zhejiang Province(JBZX-202007)
通讯作者:胡坚,Email:dr_hujian@zju.edu.cn
Corresponding Author: HU Jian, Email: dr_hujian@zju.edu.cn
引用格式:倪恒,陆豪健,王一青,等 . 机器人与胸腔镜袖式肺叶切除术治疗非小细胞肺癌的比较研究 [J]. 机器人外科学杂志(中英文),2022,3(1):15-21.
Citation: NI H, LU H J, WANG Y Q, et al. Comparison study of robotic and thoracoscopic sleeve lobectomy in treating non-small cell lung cancer [J]. Chinese Journal of Robotic Surgery, 2022, 3 (1): 15-21.
[1] Siegel R L, Miller K D, Jemal A. Cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70 (1): 7-30.
[2] FENG R M, ZONG Y N, CAO S M, et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics? [J]. Cancer Commun (Lond), 2019, 39 (1): 22.
[3] ZHANG Y K, CHAI Z D, TAN L L, et al. Association of lymph node involvement with the prognosis of pathological T1 invasive non-small cell lung cancer [J]. World J Surg Oncol, 2017, 15 (1): 64-71.
[4] Hirsch F R, Scagliotti G V, Mulshine J L, et al. Lung cancer: current therapies and new targeted treatments[J]. The Lancet, 2017. DOI: 10.1016/S0140- 6736 (16)30958-8.
[5] Goldstraw P, Chansky K, Crowley J, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (Eighth) edition of the TNM classification for lung cancer[J]. J Thorac Oncol, 2016, 11 (1): 39-51.
[6] Field J K, Oudkerk M, Pedersen J H, et al. Prospects for population screening and diagnosis of lung cancer [J]. The Lancet, 2013, 382 (9893): 732-741.
[7] National Lung Screening Trial Research Team, Church T R, Black W C, et al. Results of initial low-dose computed tomographic screening for lung cancer [J]. N Engl J Med, 2013, 368 (21): 1980-1991.
[8] Rossi D. What can we save for the first-line treatment of NSCLC in 2016? [J]. World J Oncol, 2017, 8 (2): 31-33.
[9] JIAO W J, ZHAO Y, QIU T, et al. Robotic bronchial sleeve lobectomy for central lung tumors: technique and outcome [J]. Ann Thorac Surg, 2019, 108 (1): 211-218.
[10] LIU L , MEI J , PU Q , et al. Thoracoscopic bronchovascular double sleeve lobectomy for non-smallcell lung cancer[J]. Eur J Cardiothorac Surg, 2014, 46 (3): 493-495.
[11] HUANG J, LI J, QIU Y, et al. Thoracoscopic double sleeve lobectomy in 13 patients: a series report from multi-centers [J]. J Thorac Dis, 2015, 7 (5): 834-842.
[12] Mayne N R, Darling A J, Raman V, et al. Perioperative outcomes and 5-year survival after open versus thoracoscopic sleeve resection for lung cancer [J]. Semin Thorac Cardiovasc Surg, 2020. DOI: 10.1053/ j.semtcvs.2020.08.013.
[13] Pardolesi A, Park B, Petrella F, et al. Robotic anatomic segmentectomy of the lung: technical aspects and initial results[J]. Ann Thorac Surg, 2012, 94 (3): 929-934.
[14] Kaur M N, Xie F, Shiwcharan A, et al. Robotic versus video-assisted thoracoscopic lung resection during early program development[J]. Ann Thorac Surg, 2018, 105 (4): 1050-1057.
[15] Gharagozloo F, Margolis M, Tempesta B, et al. Robotassisted lobectomy for early-stage lung cancer: report of 100 consecutive cases[J]. Ann Thorac Surg, 2009, 88 (2): 380-384.
[16] Balduyck B, Hendriks J, Lauwers P, et al. Quality of life after lung cancer surgery: a prospective pilot study comparing bronchial sleeve lobectomy with pneumonectomy[J]. J Thorac Oncol, 2008, 3 (6): 604-608.
[17] Pagès P B, Mordant P, Renaud S, et al. Sleeve lobectomy may provide better outcomes than pneumonectomy for non-small cell lung cancer. A decade in a nationwide study [J]. J Thorac Cardiovasc Surg, 2017, 153 (1): 184-195.
[18] Chen J, Soultanis K M, Sun F, et al. Outcomes of sleeve lobectomy versus pneumonectomy: a propensity scorematched study[J]. J Thorac Cardiovasc Surg, 2020. DOI: 10.1016/j.jtcvs.2020.08.027.
[19] Maurizi G, D’Andrilli A, Anile M, et al. Sleeve lobectomy compared with pneumonectomy after induction therapy for non-small-cell lung cancer [J]. J Thorac Oncol, 2013, 8 (5): 637-643.
[20] 潘茂杰 , 魏煜程 . 袖式肺叶切除术在非小细胞肺癌中的应用 [J]. 中国胸心血管外科临床杂志 , 2018, 25 (6): 526-532.
[21] GAO H J, JIANG Z H, GONG L, et al. Video-assisted vs thoracotomy sleeve lobectomy for lung cancer: a propensity matched analysis [J]. Ann Thorac Surg, 2019, 108 (4): 1072-1079.
[22] DENG H Y, QIU X M, ZHU D X, et al. Video-assisted thoracoscopic sleeve lobectomy for centrally located non-small cell lung cancer: a meta-analysis[J]. World J Surg, 2020. DOI: 10.1007/s00268-020-05877-5.
[23] Spaggiari L, Sedda G, Maisonneuve P, et al. A brief report on survival after robotic lobectomy for earlystage lung cancer [J]. J Thorac Oncol, 2019, 14 (12): 2176-2180.
[24] 张斯渊 , 董信春 , 苟云久 , 等 . 达芬奇机器人辅助支气管袖式肺叶切除术的围术期疗效和安全性分析 [J]. 中国胸心血管外科临床杂志 , 2020, 27 (10): 1145-1149.
[25] 王希龙 , 许世广 , 刘博 , 等 . 机器人肺叶袖式切除成形及支气管成形术的可行性及质量控制 [J]. 中国 胸心血管外科临床杂志 , 2020, 27 (2): 190-194.
[26] Yang H X, Woo K M, Sima C S, et al. Long-term survival based on the surgical approach to lobectomy for clinical stage Ⅰ non-small cell lung cancer: comparison of robotic, video-assisted thoracic surgery, and thoracotomy lobectomy[J]. Ann Surg, 2017, 265 (2): 431-437.
[27] Medbery R L, Gillespie T W, Liu Y, et al. Nodal upstaging is more common with thoracotomy than with vats during lobectomy for early-stage lung cancer: an analysis from the National Cancer Data Base[J]. J Thorac Oncol, 2016, 11 (2): 222-233.
[28] Merritt R E, Hoang C D, Shrager J B. Lymph node evaluation achieved by open lobectomy compared with thoracoscopic lobectomy for N0 lung cancer [J]. Ann Thorac Surg, 2013, 96 (4): 1171-1177.
[29] 王先进 , 钟山 , 沈周俊 . 机器人手术的经济学探 讨 [J]. 上海医学 , 2011, 34 (1): 70-73.
[30] 吴晓 , 徐金明 , 王莺 , 等 . 机器人与胸腔镜肺段切除术治疗非小细胞肺癌的倾向性评分匹配研究 [J]. 中国胸心血管外科临床杂志 , 2020, 27 (10): 1150-1154.
[31] QIU T, ZHAO Y, XUAN Y, et al. Robotic sleeve lobectomy for centrally located non-small cell lung cancer: a propensity score-weighted comparison with thoracoscopic and open surgery [J]. J Thorac Cardiovasc Surg, 2020, 160 (3): 838-846 e832.