目的:探讨局限性前列腺癌患者采用改良 Vattikuti 研究所前列腺切除术(VIP)技术行机器人辅助腹 腔镜下根治性前列腺切除术(RARP)治疗的临床疗效。方法:回顾性分析 2022 年 1 月—2023 年 6 月在宝鸡市中心 医院泌尿外科行 RARP 的 53 例局限性前列腺癌患者的临床资料。根据手术方式不同,分为标准前入路 RARP(SARARP)组和改良 VIP RARP(MV-RARP)组,其中 SA-RARP 组 24 例,MV-RARP 组 29 例。收集并比较两组患者 围手术期指标及术后随访资料。结果:两组患者均顺利完成手术,未出现中转开放手术及二次手术,两组一般资料 比较,差异均无统计学意义(P>0.05)。两组患者的手术时间、术中出血量、术中输血率、术后住院时间、术后引 流管拔除时间、术后导尿管拔除、切缘阳性率、扩大淋巴结清扫率、淋巴结阳性率、Gleason 评分、临床分期比较, 差异无统计学意义(P>0.05)。与 SA-RARP 组相比,MV-RARP 组即刻尿控、早期尿控及 3 个月尿控恢复情况均更优, IIEF-5 评分更高(P<0.05)。采用 Kaplan-Meier 生存曲线分析两组患者无生化复发生存时间,差异无统计学意义 (Log-Rank:χ 2 =0.889,P=0.346)。采用Kaplan-Meier生存曲线分析两组患者尿控恢复率,差异有统计学意义(Log-Rank: χ 2 =4.314,P=0.038)。结论:改良 VIP 技术是一种精准、安全的前列腺癌根治技术,可以在保证良好肿瘤控制的基 础上,提高术后早期尿控恢复率,改善术后勃起功能。
Objective: To investigate the clinical efficacy of modified Vattikuti Institute Prostatectomy (VIP) technique in patients underwent robot-assisted laparoscopic radical prostatectomy (RARP) for localized prostate cancer. Methods: Clinical data of 53 patients with localized prostate cancer who underwent RARP in Baoji Central Hospital from January 2022 to June 2023 were retrospectively analyzed. According to the different surgical approaches, they were divided into the standard anterior approach robot-assisted laparoscopic radical prostatectomy (SA-RARP) group (n=24) and modified VIP RARP (MV-RARP) group (n=29). Perioperative indicators and follow-up data were collected and compared between the two groups. Results: All surgeries were successfully completed without conversion to open surgery or secondary surgery. There were no statistically significant differences in general data of patients in the two groups (P>0.05). The differences in operative time, intraoperative bleeding, intraoperative blood transfusion rate, postoperative hospitalization time, drainage tube removal time, postoperative catheter removal, positive surgical margin rate, enlarged lymph node dissection rate, positive lymph node rate, Gleason score, and clinical stage of the two groups were not statistically significant (P>0.05). Compared with the SA-RARP group, the MVRARP group had better immediate urinary control, early urinary control and 3-month urinary control, and higher IIEF-5 score (P<0.05). Kaplan-Meier curve was used to analyze the survival time without biochemical recurrence in the two groups, and the difference was not statistically significant (Log-Rank:χ 2 =0.889, P=0.346). The Kaplan-Meier survival analysis indicated that the difference in recovery rate of urinary control of the two groups was statistically significant (Log-Rank:χ 2 =4.314, P=0.038). Conclusion: The modified VIP technique is a precise and safe technique in RARP for prostate cancer, which can improve the recovery rate of early postoperative urinary control and postoperative erectile function by ensuring good tumor control.
收稿日期:2024-02-06 录用日期:2024-04-28
Received Date: 2024-02-06 Accepted Date: 2024-04-28
基金项目:陕西省卫生健康科研基金项目(2021C002)
Foundation Item: Health Research Founding project of Shaanxi Province (2021C002)
通讯作者:罗晓辉,Email:luoxiaohuidoctor@163.com
Corresponding Author: LUO Xiaohui, Email: luoxiaohuidoctor@163.com
引用格式:黄晓东,王晨青,樊俊杰,等 . 改良 VIP 技术在机器人辅助腹腔镜下根治性前列腺切除术中的应用研究(附手术视频)[J]. 机器人外科学杂志(中英文),2024,5(6):1047-1055.
Citation: HUANG X D, WANG C Q, FAN J J, et al. Application of modified VIP technique in robot-assisted laparoscopic radical prostatectomy (with surgical video)[J]. Chinese Journal of Robotic Surgery, 2024, 5(6): 1047-1055.
[1] Siegel R L, Miller K D, Fuchs H E, et al. Cancer statistics, 2022[J]. CA Cancer J Clin, 2022, 72(1): 7-33.
[2] XIA C F, DONG X S, LI H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants[J]. Chin Med J(Engl), 2022, 135(5): 584-590.
[3] Mottet N, van den Bergh R C N, Briers E, et al. EAU-EANM-ESTROTSUR-SIOG Guidelines on Prostate Cancer-2020 update. Part 1: Screening, diagnosis, and local treatment with curative intent[J]. Eur Urol, 2021, 79(2): 243-262.
[4] Menon M, Tewari A, Peabody J, et al. Vattikuti institute prostatectomy : technique[J]. J Urol, 2003, 169(6): 2289-2292.
[5] Savera A T, Kaul S, Badani K, et al. Robotic radical prostatectomy with the “Veil of Aphrodite” technique: histologic evidence of enhanced nerve sparing[J]. Eur Urol, 2006, 49(6): 1065-1073.
[6] Menon M, Shrivastava A, Bhandari M, et al. Vattikuti institute prostatectomy : technique modifications in 2009[J]. Eur Urol, 2009, 56(1): 89-96.
[7] 中国医促会泌尿健康促进分会 , 中国研究型医院学会泌尿外科 学专业委员会 . 腹腔镜 ( 含机器人辅助 ) 前列腺癌根治术安全 共识 [J]. 现代泌尿外科杂志 , 2020, 25(7): 575-584.
[8] 韩邦旻 , 李文智 , 马鑫 , 等 . 机器人辅助前列腺癌根治术尿控功 能的保留专家共识 [J]. 微创泌尿外科杂志 , 2023, 12(1): 25-29.
[9] Albisinni S, Dasnoy C, Diamand R, et al. Anterior vs. Retzius-sparing robotic assisted radical prostatectomy: can the approach really make a difference?[J]. Minerva Urol Nephrol, 2021, 74(2): 137-145.
[10] Bahouth Z, Laniado M, Fowler R, et al. Positive surgical margins rate of Retzius-sparing robot-assisted radical prostatectomy in a contemporary, unselected cohort[J]. J Urol, 2022, 207(3): 609-616.
[11] van Kollenburg R A A, de Bruin D M, Wijkstra H. Validation of the electronic version of the international index of erectile function (IIEF-5 and IIEF-15): a crossover study[J]. J Med Internet Res, 2019, 21(7): e13490.
[12] 李名城 , 张学平 , 章语 . 机器人辅助手术在前列腺癌患者中的 应用效果及术后并发症分析 [J]. 机器人外科学杂志 ( 中英文 ), 2023, 4(3): 227-232.
[13] Cho E Y, Yang K K, Lee Z, et al. A review of technical progression in the robot-assisted radical prostatectomy[J]. Transl Androl Urol, 2021, 10(5): 2171-2177.
[14] 魏强 . 保留盆底稳定结构结合前方高位松解并逆向分离神经血 管束的机器人辅助根治性前列腺切除术 [J]. 中华泌尿外科杂志 , 2022, 43(7): 534.
[15] Bianchi L, Turri F M, Larcher A, et al. A novel approach for apical dissection during robot-assisted radical prostatectomy: the “collar” technique[J]. Eur Urol Focus, 2018, 4(5): 677-685.
[16] Yamashita K, Kijima Y, Sekido E, et al. Predictors of longterm urinary incontinence after robot-assisted laparoscopic prostatectomy[J]. Res Rep Urol, 2023, 15: 387-393. DOI: 10.2147/ RRU.S419903.
[17] Mungovan S F, Sandhu J S, Akin O, et al. Preoperative membranous urethral length measurement and continence recovery following radical prostatectomy: a systematic review and meta-analysis[J]. Eur Urol, 2017, 71(3): 368-378.
[18] 曲发军 , 张宗勤 , 吴震杰 , 等 . 联合保留最大尿道长度和膀胱颈 的尿道重建术在机器人前列腺癌根治术早期尿控中的应用 [J]. 机器人外科学杂志 ( 中英文 ), 2020, 1(3): 174-179.
[19] Martini A, Falagario U G, Villers A, et al. Contemporary techniques of prostate dissection for robot-assisted prostatectomy[J]. Eur Urol, 2020, 78(4): 583-591.
[20] Cochetti G, Boni A, Barillaro F, et al. Full neurovascular sparing extraperitoneal robotic radical prostatectomy: our experience with PERUSIA technique[J]. J Endourol, 2017, 31(1): 32-37.
[21] 常易凡 , 徐伟东 , 朱亚生 , 等 .“超级面纱法”腹膜外单孔机器 人前列腺癌根治术的手术技巧体会及临床应用分析 [J]. 临床泌 尿外科杂志 , 2022, 37(1): 6-10, 14.
[22] 任善成 , 冀明 , 常易凡 . 保留前列腺周围解剖结构在机器人 前列腺癌根治术中的应用 [J]. 现代泌尿外科杂志 , 2019, 24(7): 511-515.
[23] Kyriazis I, Spinos T, Tsaturyan A, et al. Different nerve-sparing techniques during radical prostatectomy and their impact on functional outcomes[J]. Cancers (Basel), 2022, 14(7): 1601.
[24] Moschovas M C, Patel V. Neurovascular bundle preservation in robotic-assisted radical prostatectomy: How I do it after 15.000 cases[J]. Int Braz J Urol, 2022, 48(2): 212-219.
[25] LI H, YANG C, LIAO Z H, et al. Modified anterior approach preserving Retzius space versus standard anterior approach robotassisted radical prostatectomy: a matched-pair analysis[J]. Front Oncol, 2023, 13: 1108202. DOI: 10.3389/fonc.2023.1108202.
[26] 郭宏骞 , 庄君龙 , 邱雪峰 , 等 . 机器人辅助腹腔镜前列腺癌根治 术精准化发展趋势 [J]. 中国肿瘤外科杂志 , 2019, 11(2): 77-82.
[27] Lambert E, Allaeys C, Berquin C, et al. Is it safe to switch from a standard anterior to Retzius-sparing approach in robot-assisted radical prostatectomy?[J]. Curr Oncol, 2023, 30(3): 3447-3460.
[28] 徐林锋 , 马浩鑫 , 邱雪峰 , 等 . 保留 Retzius 间隙的机器人辅 助前列腺癌根治术 100 例报告 [J]. 临床泌尿外科杂志 , 2017, 32(8): 595-598.
[29] 黄海 , 马晓明 , 刘皓 , 等 . 机器人辅助腹腔镜前列腺癌根治术的 进展 [J]. 中华腔镜泌尿外科杂志 ( 电子版 ), 2018, 12(3): 145-148.
[30] Falagario U G, Knipper S, Pellegrino F, et al. Prostate cancer-specific and all-cause mortality after robot-assisted radical prostatectomy: 20 years’ report from the European Association of Urology Working Group[J]. Eur Urol Oncol, 2024, 7(4): 705-712.
[31] Galfano A, Tappero S, Eden C, et al. Multicentric experience in Retzius-sparing robot-assisted radical prostatectomy performed by expert surgeons for high-risk prostate cancer[J]. Minerva Urol Nephrol, 2022, 74(5): 607-614.
[32] 周利群 , 蔡宇坤 , 洪鹏 , 等 . 北京大学泌尿外科研究所改良的腹 腔镜下腹膜外前列腺癌根治术 : IUPU 改良 VIP 术 [J]. 中华腔镜 泌尿外科杂志 ( 电子版 ), 2019, 13(1): 1-4.