目的:分析 3D 打印辅助聚甲基丙烯酸甲酯(PMMA)骨水泥髓内支撑在 Neer Ⅱ、Ⅲ、Ⅳ型肱骨近端骨质疏松性骨 折治疗中的应用。方法:回顾性分析 2021 年 10 月—2023 年 11 月在通用医疗汉中三二〇一医院接受 3D 打印辅助 PMMA 骨 水泥髓内支撑治疗的 90 例老年肱骨近端骨质疏松性骨折患者的临床资料,根据 Neer 分型将所有患者分为 Neer Ⅱ型骨折组 (n=28)、Neer Ⅲ型骨折组(n=37)和 Neer Ⅳ型骨折组(n=25),并观察患者的康复情况。结果:三组患者术前患侧颈干 角显著小于健侧颈干角(P<0.05),而术后 6 个月患侧颈干角与健侧颈干角比较,差异无统计学意义(P>0.05)。三组患者 术中与术后 6 个月的肱骨头高度差值均 <5 mm。三组患者术后不同时点的 VAS 评分和 Constant-Murley 评分均低于术前,差 异有统计学意义(P<0.05);各组内不同时点评分两两比较,差异有统计学意义(P<0.05)。与术前相比,三组患者术后 6 个月的生活质量各维度评分明显升高,差异有统计学意义(P<0.05)。结论:对老年 Neer II、III、IV 型肱骨骨质疏松性骨 折患者行 3D 打印辅助 PMMA 骨水泥髓内支撑治疗能有效促进患者术后恢复,效果良好。
Objective: Analyze the application of 3D printing-assisted polymethylmethacrylate (PMMA) bone cemented intramedullary support in the treatment of Neer II, III, and IV osteoporotic fracture of the proximal humerus. Methods: 90 elderly patients with osteoporotic fractures of the proximal humerus who were treated with 3D printing-assisted PMMA bone cemented intramedullary support in General Healthcare Hanzhong 3201 Hospital from October 2021 to November 2023 were retrospectively selected and divided into the Neer II fracture group (n=28), the Neer III fracture group (n=37) and the Neer IV fracture group (n=25) according to the Neer classification, and the rehabilitation conditions of patients was observed. Results: The preoperative humeral neck-shaft angle of the affected side was all significantly smaller than that of the healthy side in the three groups (P<0.05), whereas the difference was not statistically significant at 6 months after surgery (P>0.05). The differences in humeral head height between intraoperative and postoperative 6-month measurements were all <5 mm in the three groups. VAS scores and Constant-Murley scores at different postoperative timepoints were all significantly lower than those befor surgery in the three groups (P<0.05), and the scores at different timepoints in pairwise comparisons showed significant differences (P<0.05). The scores on quality of life in all dimensions were significantly increased in the three groups at 6 months postoperatively compared with those before surgery (P<0.05). Conclusion: Application of 3D printing-assisted PMMA bone cement intramedullary support in treating elderly Neer type II, III, and IV osteoporotic fractures of the humerus can effectively promote the postoperative recovery and has a good application effect.
基金项目:陕西省重点研发计划项目(2019-SF-168)
Foundation Item: Key R&D Plan Project of Shaanxi Province(2019-SF-168)
引用格式:尹伟,于洋,宋永财,等 . 3D 打印辅助 PMMA 骨水泥髓内支撑在肱骨近端骨质疏松性骨折治疗中的应用 [J]. 机器人外科学杂志 (中英文),2025,6(3):373-378.
Citation: YIN W, YU Y, SONG Y C, et al. Application of 3D printing-assisted PMMA bone cement intramedullary support in the treatment of osteoporotic fractures of the proximal humerus[J]. Chinese Journal of Robotic Surgery, 2025, 6(3): 373-378.
通讯作者(Corresponding Author):杨立峰(YANG Lifeng),Email:hunanylf@163.com
[1] Rehm A, Novak P L, Newton A, et al. Does radiation exposure during pediatric supracondylar humeral fracture surgery change according to the C-arm position? A comparison of two different techniques[J]. Injury, 2024, 55(3): 111354.
[2] Radaideh A M, Rusan M, Obeidat O, et al. Functional and radiological outcomes of different pin configuration for displaced pediatric supracondylar humeral fracture: a retrospective cohort study[J]. World J Orthop, 2022 , 13(3): 250-258.
[3] Lee Y J, Lim J R, Choi J H, et al. Comparing the biomechanical stability of cerclage cable with plate insert versus locking screw in periprosthetic humeral fracture[J]. J Bone Joint Surg Am, 2024, 106(9): 817-822.
[4] Chua N, Onggo J R, Nambiar M, et al. Functional outcomes of reverse total shoulder arthroplasty in Boileau class 1 and class 2 proximal humeral fracture sequelae: a meta-analysis and systematic review[J]. Shoulder Elbow, 2023, 15(3 Suppl): 43-53.
[5] Van Bergen S H, Van Lieshout E M M, Mahabier K C, et al. Publisher correction: Economic evaluation of operative versus nonoperative treatment of a humeral shaft fracture: economic analyses alongside a multicenter prospective cohort study (HUMMER) [J]. Eur J Trauma Emerg Surg, 2023, 49(2): 939.
[6] Hartog D D, Mahabier K C, Van Bergen S H, et al. Functional and clinical outcomes after plate osteosynthesis versus intramedullary nailing of a humeral shaft fracture: the results of the HUMMER multicenter, prospective cohort study[J]. J Bone Joint Surg Am, 2023, 105(14): 1101-1111.
[7] Shih C A, Huang M T, Chern T C, et al. The use of ultrasound for monitoring reduction and ulnar nerve subluxation in pediatric humeral supracondylar fractures[J]. Eur J Radiol, 2024, 170: 111201.
[8] Panagopoulos A, Solou K, Symeonidis A, et al. Delayed diagnosis of a primary diffuse large B-cell lymphoma of the humeral head, presenting as pathological fracture: a case report and review of the literature[J]. JSES Rev Rep Tech, 2024, 4(2): 299-311.
[9] 纪振中 , 张奕 , 张明 , 等 . 3D 打印骨折模型在复杂骨盆骨折手术中 的治疗方法及效果探讨 [J]. 中国医学装备 , 2022, 19(1): 111-115.
[10] 张成川 , 梁建 , 盛雷 , 等 . 3D 打印联合急诊外侧入路手术治疗创伤 性跟骨骨折的有效性及对应激、炎症因子的影响 [J]. 临床和实验医 学杂志 , 2023, 22(1): 42-47.
[11] 刘峰 , 雷青 , 蔡立宏 , 等 . 改良经皮三维打印导板与传统透视辅助骶 髂螺钉固定骨盆后环骨折的疗效比较 [J]. 中南大学学报 ( 医学版 ), 2023, 48(11): 1703-1710.
[12] 王清泽 , 罗明星 , 曾帅 , 等 . 3D 打印经皮手术导板在股骨颈骨折闭合 复位空心螺钉内固定术中的应用 [J]. 中国骨伤 , 2023, 36(3): 209-215.
[13] 金万通 , 薛海鹏 , 周大鹏 , 等 . 3D 打印结合 PMMA 骨水泥髓内支撑 技术在老年肱骨近端骨质疏松性骨折中的应用 [J]. 中华老年骨科与 康复电子杂志 , 2022, 8(5): 276-284.
[14] Rudran B, Little C, Duff A, et al. Proximal humerus fractures: anatomy, diagnosis and management[J]. Br J Hosp Med (Lond), 2022, 83(7): 1-10.
[15] Katthagen J C, Koeppe J, Stolberg-Stolberg J, et al. Effects of antiosteoporosis therapy on the risk of secondary fractures and surgical complications following surgical fixation of proximal humerus fracture in older people[J]. Age Ageing, 2023, 52(6): afad097.
[16] Bieling M, Ellwein A, Lill H, et al. Proximal humerus fracture and acromioclavicular joint dislocation[J]. Innov Surg Sci, 2024, 9(2): 67-82.
[17] 蒋维利 , 刘涛 , 张青波 , 等 . 基于 3D 打印技术改良单边经皮穿刺椎 体成形术治疗骨质疏松性椎体压缩性骨折 [J]. 中国骨伤 , 2024, 37(1): 7-14.
[18] 韦昌辉 , 张伟 , 卢俊浩 , 等 . 3D 打印辅助经皮穿刺椎体成形术治疗 重度骨质疏松性椎体压缩骨折的疗效 [J]. 局解手术学杂志 , 2023, 32(10): 910-914.
[19] 常丽鹏 , 申军 , 赵敏 , 等 . 3D 打印数字技术辅助经皮穿刺椎体成形术 治疗重度骨质疏松性椎体压缩骨折的临床效果 [J]. 安徽医学 , 2019, 40(12): 1327-1331.
[20] 金浪 , 石洁 , 黄正 , 等 . 3D 打印数字技术辅助改良交叉 PVP 对重度 骨质疏松性椎体压缩骨折脊柱 - 骨盆矢状面平衡状态的影响 [J]. 中 华老年骨科与康复电子杂志 , 2023, 9(5): 263-268.
[21] 王伟斌 , 袁欣华 , 扶青松 , 等 . 骨质疏松性肱骨近端骨折 PMMA 骨水 泥强化螺钉钢板固定的有限元分析 [J]. 中国骨伤 , 2023, 36(3): 262-267.
[22] 董宇鹏 , 高顺红 , 张云鹏 , 等 . Masquelet 技术治疗尺桡骨感染性骨缺 损的疗效分析 [J]. 中国骨与关节损伤杂志 , 2023, 38(9): 980-982.
[23] 汤小迪 , 虎鑫 , 卢敏勋 , 等 . 3D 打印金属支撑假体联合关节面自体 骨植骨治疗股骨远端 Campanicci Ⅰ、Ⅱ级骨巨细胞瘤的早期随访研 究 [J]. 中国骨与关节杂志 , 2023, 12(3): 168-175.
[24] 王洪平 , 王明友 , 杨晓琴 , 等 . 3D 打印技术在复杂慢性髋关节假体 周围感染中的临床研究 [J]. 四川医学 , 2023, 44(6): 615-619.
[25] CHEN N. Embedded 3D printing and pressurized thermo-curing of PMMA for medical implants[J]. J Mech Behav Biomed Mater, 2023, 1(46): 106083.
[26] Csámer L, Csernátony Z, Novák L, et al. Custom-made 3D printing-based cranioplasty using a silicone mould and PMMA[J]. Sci Rep, 2023, 13(1): 11985.
[27] Beitler B, Roytman G R, Parmer G, et al. Evaluating surface coatings to reduce bone cement adhesion to point of care 3D printed molds in the intraoperative setting[J]. 3D Print Med, 2022, 8(1): 28.
[28] Hasanzade M, Yaghoobi N, Nematollahi P, et al. Comparison of the marginal and internal fit of PMMA interim crowns printed with different layer thicknesses in 3D-printing technique[J]. Clin Exp Dent Res, 2023, 9(5): 832-839.
[29] de Souza F A, Blois M C, Collares K, et al. 3D-printed and conventional provisional single crown fabrication on anterior implants: A randomized clinical trial[J]. Dent Mater, 2024, 40(2): 340-347.
[30] Barros M C, Mazzon R R, Soto A F, et al. Candida albicans adhesion on 3D-printed and thermopolymerizable polymethyl methacrylate for removable prostheses[J]. Am J Dent, 2023, 36(3): 130-135.
[31] Saini R S, Gurumurthy V, Quadri S A, et al. The flexural strength of 3D-printed provisional restorations fabricated with different resins: a systematic review and meta-analysis[J]. BMC Oral Health, 2024, 24(1): 66.