目的：探讨丙泊酚靶控输注麻醉与七氟烷吸入麻醉对机器人辅助腹腔镜下根治性前列腺切除术中患者脑氧代谢及认知 功能的影响。方法：选取 2021 年 2 月—2023 年 8 月西安国际医学中心医院收治的 122 例行机器人辅助腹腔镜下根治性前列 腺切除术患者作为研究对象，按照随机数表法将所有患者分为研究组（丙泊酚靶控输注麻醉，n=61）和对照组（七氟烷吸入 麻醉，n=61）。比较两组患者恢复指标、脑氧饱和度、认知功能（MMSE 评分）及不良反应发生情况。结果：相较于对照组， 研究组呼吸恢复时间、睁眼时间、拔管时间、出室时间均更低（P<0.05）。相较于诱导前，两组吸氧时、诱导后 5 min、术中、 术毕脑氧饱和度均降低（P<0.05），但研究组术中、术毕、睁眼时脑氧饱和度高于对照组（P<0.05）。相较于诱导前，两组 睁眼时、术后 1 d MMSE 评分均降低（P<0.05），但研究组睁眼时、术后 1 d MMSE 评分高于对照组（P<0.05）。比较两组不 良反应发生率，差异无统计学意义（P>0.05）。结论：机器人辅助腹腔镜下根治性前列腺切除术中应用丙泊酚靶控输注麻醉 可有效保持患者脑氧饱和度正常，促进术后恢复，减少其对认知功能的影响，且安全性较好。

Objective: To Explore the effects of propofol target-controlled infusion anesthesia and sevoflurane inhalation anesthesia on cerebral oxygen metabolism and cognitive function in patients undergoing robot-assisted laparoscopic radical prostatectomy (RARP). Methods: 122 patients who underwent RARP from February 2021 to August 2023 in Xi’an International Medical Center Hospital were selected and divided into the study group (n=61, propofol target-controlled infusion anesthesia) and the control group (n=61, sevoflurane inhalation anesthesia) using a random number table. The recovery indicators, cerebral oxygen saturation, cognitive function (MMSE score), and adverse reactions were compared between the two groups of patients. Results: The respiratory recovery time, eye-opening time, and extubation time were lower in the study group than those in the control group (P<0.05). Compared with that before induction, cerebral oxygen saturation was both decreased in the two groups during oxygenation, 5 minutes after induction, during and after surgery (P<0.05), while the cerebral oxygen saturation in the study group was higher than that in the control group at the time of during and after surgery, and eye-opening (P<0.05). Compared with that before induction, MMSE scores at eye-opening and 1 day after surgery were both decreased in the two groups (P<0.05), but they were relatively higher in the study group (P<0.05). There was no statistically significant difference in the complication rates between the two groups (P<0.05). Conclusion: The application of propofol target-controlled infusion anesthesia in patients undergoing RARP radical prostatectomy can effectively and safely maintain normal cerebral oxygen saturation, promote postoperative recovery, reduce its impact on cognitive function.

基金项目：陕西省重点研发计划项目（2022SF-487） 

Foundation Item: Key R&D Plan Project of Shaanxi Province(2022SF-487) 

引用格式：商燕，梁静，吕玉珠，等 . 丙泊酚靶控输注麻醉与七氟烷吸入麻醉对机器人辅助腹腔镜下根治性前列腺切除术中患者脑氧代谢及 认知功能的影响 [J]. 机器人外科学杂志（中英文），2025，6（2）：251-255. 

Citation: SHANG Y, LIANG J, LYU Y Z, et al. Effects of propofol target-controlled infusion anaesthesia and sevoflurane inhalation  anaesthesia on cerebral oxygen metabolism and cognitive function in patients undergoing robot-assisted laparoscopic radical  prostatectomy [J]. Chinese Journal of Robotic Surgery, 2025, 6(2): 251-255. 

通讯作者（Corresponding Author）：李艳（LI Yan），Email：41346027@qq.com

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