目的:探讨机器人辅助保留十二指肠胰头切除术治疗婴儿局灶型先天性高胰岛血症(CHI)的安全性和可行性。 方法:广州医科大学附属妇女儿童医疗中心肝胆外科于 2024 年 1 月—2024 年 3 月收治 2 例胰头局灶型 CHI 患儿, 行机器人辅助保留十二指肠胰头切除术 + 胰体空肠 Roux-en-Y 吻合术,收集并分析患儿的临床资料。结果:2 例患 儿均成功完成机器人辅助手术,手术时间分别为405 min和350 min,术中出血量分别为3 mL和5 mL,术后恢复顺利, 无胰瘘或胆瘘。患儿在正常奶量的情况下血糖维持在正常范围。结论:机器人手术系统具有较好的清晰度和操作 灵活性,初步应用于局灶型 CHI 婴儿保留十二指肠胰头切除术是安全、可行的。
Objective: To investigate the safety and feasibility of robot-assisted duodenum-preserving pancreatic head resection for the treatment of focal congenital hyperinsulinism (CHI) in infants. Methods: 2 infants with focal CHI on the pancreatic head in the Department of Hepatobiliary Surgery of the Women’s and Children’s Medical Center Affiliated to Guangzhou Medical University from January 2024 to March 2024 were selected. Robot-assisted duodenum-preserving pancreatic head resection with pancreatico-jejunal Roux-en-Y anastomosis was performed, and the clinical data were collected and analyzed. Results: Robot-assisted surgery was successfully completed in the two infants, with an operative time of 405 min and 350 min, intraoperative bleeding of 3 mL and 5 mL, and smooth postoperative recovery without pancreatic fistula or biliary fistula. The infants’ blood glucose was maintained in the normal range under normal milk intake. Conclusion: There is good clarity and operational flexibility with the robotic surgical system, and it is safe and feasible to apply it initially for duodenum-preserving pancreatic head resection in infants with focal CHI.
基金项目:广东省自然科学基金项目(2024A1515013217)
Foundation Item: Natural Science Foundation of Guangdong Province(2024A1515013217)
通讯作者:温哲,Email:wenzhe2005@163.com
Corresponding Author: WEN Zhe, Email: wenzhe2005@163.com
引用格式:梁奇峰,温哲,白晓玲,等 . 机器人辅助保留十二指肠胰头切除术治疗婴儿高胰岛素血症的病例探讨(附手术视频)[J]. 机器人外科学杂志(中英文),2025,6(1):90-94,100.
Citation: LIANG Q F, WEN Z, BAI X L, et al. Exploration of robot-assisted duodenum-preserving pancreatic head resection for the treatment of hyperinsulinism in infants (with surgical video) [J]. Chinese Journal of Robotic Surgery, 2025, 6(1): 90-94, 100.
[1] Arnoux J B, Verkarre V, Saint-Martin C, et al. Congenital hyperinsulinism current trends in diagnosis and therapy[J]. Orphanet J Rare Dis, 2011, 3(6): 63.
[2] Yorifuji T, Horikawa R, Hasegawa T, et al. Clinical practice guidelines for congenital hyperinsulinism[J]. Clin Pediatr Endocrinol, 2017, 26(3): 127-152.
[3] Han B, Mohamed Z, Estebanez M S, et al. Atypical forms of congenital hyperinsulinism in infancy are associated with mosaic patterns of immature islet cells[J]. J Clin Endocrinol Metab, 2017, 102(9): 3261-3267.
[4] 梁奇峰 , 温哲 , 梁鉴坤 , 等 . 先天性高胰岛素血症手术治疗效果 分析 [J]. 临床小儿外科杂志 , 2021, 20(7): 612-618.
[5] Liem N T, Son T N, Hoan N T. Laparoscopic near-total pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy report of two cases[J]. J Laparoendosc Adv Surg Tech, 2010, 20(1): 115-117.
[6] WEN Z, WANG J Q, LIANG Q F, et al. Laparoscopic surgery for focal-form congenital hyperinsulinism located in pancreatic head[J]. Front Pediatr, 2022, 10: 919238. DOI: 10.3389/fped.2022.919238.
[7] Scott Adzick N. Surgical treatment of congenital hyperinsulinism[J]. Semin Pediatr Surg, 2020, 29(3): 150924.
[8] Shah P, Demirbilek H, Hussain K. Persistent hyperinsulinaemic hypoglycaemia in infancy[J]. Semin Pediatr Surg, 2014, 23(2): 76-82.
[9] Snider K E, Becker S, Boyajian L, et al. Genotype and phenotype correlations in 417 children with congenital hyperinsulinism[J]. J Clin Endocrinol Metab, 2012, 98(2): 355-363.
[10] Kapoor R R, Flanagan S E, Arya V B, et al. Clinical and molecular characterisation of 300 patients with congenital hyperinsulinism[J]. Eur J Endocrinol, 2013, 168(4): 557-564.
[11] Flanagan S E, Kapoor R R, Hussain K. Genetics of congenital hyperinsulinemic hypoglycemia[J]. Semin Pediatr Surg, 2011, 20(1): 13-17.
[12] Christiansen C D, Petersen H, Nielsen A L, et al. 18F-DOPA PET/ CT and 68Ga-DOTANOC PET/CT scans as diagnostic tools in focal congenital hyperinsulinism: a blinded evaluation[J]. Eur J Nucl Med Mol Imaging, 2018, 45(2): 250-261.
[13] Beltrand J, Caquard M, Arnoux J B, et al. Glucose metabolism in 105 children and adolescents after pancreatectomy for congenital hyperinsulinism[J]. Diabetes Care, 2012, 35(2): 198-203.
[14] Welters A, Meissner T, Grulich-Henn J, et al. Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism[J]. Orphanet J Rare Dis, 2018, 13(1): 230.
[15] Suchi M, MacMullen C M, Thornton P S, et al. Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinism[J]. Mod Pathol, 2006, 19(1): 122-129.
[16] Adzick N S, De Leon D D, States L J, et al. Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children[J]. J Pediatr Surg, 2019, 54(1): 27-32.
[17] Laje P, Stanley C A, Palladino A A, et al. Pancreatic head resection and Roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism[J]. J Pediatr Surg, 2012, 47(1): 130-135.
[18] Agostino P, Nah S A. Surgical management of congenital hyperinsulinism of infancy[J]. Semin Pediatr Surg, 2011, 20(1): 50-53.
[19] 中国抗癌协会胰腺癌专业委员会微创诊治学组 , 中华医学会 外科学分会胰腺外科学组 . 腹腔镜或机器人辅助胰腺癌根治 术中国专家共识 (2022 年版 )[J]. 中华外科杂志 , 2023, 61(3): 187-195.
[20] Casadei R, Ricci C, Pacilio C A, et al. Laparoscopic distal pancreatectomy: which factors are related to open conversion? Lessons learned from 68 consecutive procedures in a high-volume pancreatic center[J]. Surg Endosc, 2018, 32(9): 3839-3845.
[21] 郭进 , 詹渭鹏 , 狐鸣 , 等 . 完全机器人“3+2”模式下前入路与 右后入路联合胰十二指肠切除术的效果初探 [J]. 机器人外科学 杂志 ( 中英文 ), 2023, 4(2): 99-104.
[22] 金巍巍 , 鲁超 , 牟一平 , 等 . 青少年胰头部肿瘤微创手术 15 例 临床分析 [J]. 中华外科杂志 , 2020, 58(7): 512-515.